WCCC 2019: the 25th World Computer Chess Championship

WCCC 2019, the 25th World Computer Chess Championship, continued the ICGA's longitudinal computer chess experiment begun in 1974. This event was held in Macau, featured six chess engines and was won by KOMODO which thereby retained its title of World Champion. CHIRON and SHREDDER were respectively second and third

WCSC 2019: the 9th World Chess Software Championship

The 'WCSC 2019' World Chess Software Championship was the ICGA's ninth experimental test of computer chess software in a neutral hardware environment. Held in Macau, this event was won by KOMODO with JONNY and CHIRON scarcely separable in second and third

WSCC 2019: the World Speed Chess Championship

WSCC 2019 was ICGA's continuation of its investigation of top chess engines playing at Blitz tempo with the consequential loss of accuracy. It was held in Macau in parallel with the 'WCCC' classical tempo and 'WCSC' neutral-hardware events. The ICGA demonstrated that, even so, the engines play at super-GM level. On this occasion, JONNY proved incisive to win while KOMODO sustained two losses

Genetic and Hemostatic Risk Factors for Stroke

Cardiovascular disorders are the main causes of death worldwide, with stroke accounting for 9-10% of all deaths1,2. Moreover, stroke is the most frequent cause of disability in the western world3. In the Netherlands alone, over 39,000 persons are admitted to hospitals with stroke each year4. There are two main types of stroke; ischemic stroke (occurring in about 80% of cases) and hemorrhagic stroke (20%). Hemorrhagic strokes can be further subdivided into intracerebral hemorrhage (15%) and subarachnoid hemorrhage (5%). In ischemic stroke, an artery or arteriole is blocked by thrombosis or an embolus, impeding blood flow to a part of the brain and causing tissue damage in the supplied territory. Intracerebral hemorrhage, on the other hand, results from rupture of a blood vessel, leading to the formation of a hematoma in the brain parenchyma. Although ischemic stroke and intracerebral hemorrhage are in a way opposite, they share several risk factors such as coagulation abnormalities, atherosclerosis and cardiac disorders. It is known that individuals with a positive family history for cardiovascular diseases have a higher risk of stroke. This may be explained by shared environmental risk factors and socioeconomic status, similar dietary habits (e.g. high cholesterol intake), but most obviously by common genetic material. The observation of increased risk of cerebrovascular disease in first degree relatives of stroke patients has fostered the notion of a genetic component of stroke. Until a few years ago, knowledge of the genetic background of stroke risk was limited, and mostly derived from small, family-based linkage studies5. Since the beginning of this millennium, however, advances in genomics have skyrocketed, paving the way for very large genetic studies6. New genetic risk factors are discovered continuously, rapidly increasing our knowledge on the genetics of complex diseases. Also in stroke, these studies are being undertaken to gain more insight in the role of genetic factors in stroke etiology